Editorial / Featured Articles / Industry News

The Growth Factor Creating International Buzz

SYNPLA is the all-new growth factor-based product that you need to get to know! 

M.A.D Skincare harnesses the ultimate benefits and power of growth factors and hyaluronic acids by introducing two revolutionary products to their Platinum Collection that will become must-haves for your treatment room!

Meet M.A.D Platinum SYNPLA Anti Wrinkle Growth Factor Serum GF 3.0/ HLA 3.0 and M.A.D Platinum SYNPLA Bright Growth Factor Serum GF 3.0/ HLA 3.0., for professionals who expect the best for their clients (and themselves)! M.A.D SYNPLA maintains skin homeostasis, helps boost elasticity, and provides superior anti-aging, brightening, moisturizing, and revitalizing benefits.

Cell Talk

SYNPLA’s formula base contains a unique blend of five different growth factors formulated to promote communication between keratinocytes and fibroblast cells. Couple these growth factors with four types of hyaluronic acid of three molecular weights, cross-linked and non-cross-linked, and you have two unparalleled Growth Factor/HLA Serums, anti-aging and brightening, for healthier, supple, youthful-looking skin. 

Growth factors function as signaling agents, facilitating interactions between cells. Since growth factors are vital for normalizing multiple cellular functions, healthy communications enable the stimulation of healthy cell reproduction, promotion of wound healing, and skin rejuvenation. Unfortunately, as we age, growth factor production slows, age spots and uneven skin tone appear, collagen and elastin production diminish, and the skin loses structural integrity producing wrinkles and sagging skin.


Sesha Skincare

4 Step Nano Facial

It combines the patented P.E.T Sesha Delivery System with the added infusion of the Nano-Tip MesoBotanica Pen. You will see immediate results after one treatment of SESHA MesoBotanica 4-Step Nano-tip Facial Protocol. We have carefully designed a protocol to ensure the client receives an enhanced version of a traditional facial with faster and better results. You will receive a complete kit that will allow you to perform the treatment on clients. There are professional-only products that you will use in the treatment and infuse with the  MesoBotanica Pen.

The Mighty SYNPLA is Born

M.A.D Platinum SYNPLA ampoules pack powerful anti-aging and brightening properties to the skin. Modeled after human placenta, M.A.Ds Growth Factor Chain is incredibly small in molecular weight and formulated to deliver unprecedented performance without the use of any human tissue during manufacturing. These tiny elements are identical to the growth factors found in real human placenta. M.A.D Platinum Growth Factor Chain is 100% synthetic, giving birth to the name SYNPLA, SYN for synthetic; and PLA for placenta.


Human Placenta?

Yes, growth factors are a foundation of life! We are all born with growth factors – in fact, they actually aid in fetal development. Growth factors stimulate fetal growth and aid in the survival of the fetus. As we grow, we continue forming growth factors. Once we reach adulthood, natural growth factor production slows, hampering the skin’s ability to repair itself. This leads to slower cell growth and signs of aging including wrinkles, dull skin, sagging skin, age spots, and thinner, less supple skin.

Time To Go Topical

Growth factors are amino acid chains, configured into building blocks that signal healthy cellular growth and boost natural cell functions including triggering cellular replication. With aging and decreased growth factor production, it becomes necessary to incorporate SYNPLA into your spa device treatments. SYNPLA replenishes natural growth factors, helping skin function more efficiently, repair damage in the skin, and trigger new cell production and cell replication, leading to rejuvenated and younger, radiant-looking skin.

SYNPLA’s active base contains a combination of five growth factors and four types of Hyaluronic Acids, delivering beneficial synergistic actions to the skin and cells.

SYNPLA’s Growth Factors and their benefits:

IGF-1 – wrinkle reduction; prevents UV induced DNA damage to cells

EGF – plays a vital role in collagen and elastin production; reduces hyperpigmentation

Fibroblast Growth Factors (Acidic FGF and Basic FGF) – responsible for the stimulation, development, and maintenance of cellular growth and health; active in anti-hyperpigmentation

Vascular Endothelial Growth Factors (VEGF) – actively fuels fibroblasts with essential nutrients, cell growth, and wound healing; contains a dynamic anti-aging active component that includes anti-wrinkle, skin rejuvenation, elasticity enhancement, moisturizing, and cell vitalization properties

SYNPLA’s Cocktail of four Hyaluronic Acids (with three molecular weights, both cross-linked and non-cross-linked) and their benefits:

Sodium Hyaluronate – a specific and naturally occurring molecule that can hold up to 1000 times its weight in water; helps reestablish younger-looking and healthier skin with restored moisture and skin’s suppleness.

Sodium Acetylated Hyaluronate – a skin-identical ingredient with a smaller molecular weight, immediately penetrates the skin and provides long-lasting moisturization; helps improve moisture levels and prevent moisture loss.

Sodium Hyaluronate Cross Polymer – a cross-linked polymer with strong moisturizing and protecting qualities; encourages collagen formation and skin’s suppleness; both protective and nutritious, its gel-like nature aids in the building of a biological layer on top of another layer enhancing the skin barrier, decreasing TEWL, and increasing moisture/water binding capacity.

Hydrolyzed Sodium Hyaluronate – a much smaller molecule than other forms of HA, deeply penetrates the dermis layer for quick absorption; helps repair damaged skin cells, squelches free radicals, and lessens the effects of aging and age spots.

In addition to M.A.D’s Growth Factor and Hyaluronic Acid Complex

SYNPLA Anti Wrinkle Growth Factor Serum is formulated with Bacillus/Soybean/Folic Acid Ferment. This powerful anti-irritation and brightening extract provides numerous benefits including anti-wrinkle, resistance against UV rays, and moisturizing.

SYNPLA Bright also includes:

Glutathione – aids in skin whitening by repairing damaged cells

Tremella Fuciformis – known as the “snow mushroom,” has proven effective on inhibiting melanogenesis and promoting wound healing, demonstrating its potential as a novel skin-whitening agent

STAY-C® 50 – significantly brightens the complexion and lightens the intensity of facial age spots

SMA’RT Niacinamide PC – an efficacious, multifunctional active aiding improvement in the skin barrier, skin elasticity, and evening skin tone (The combination of Niacinamide and Hyaluronic Acid delivers extreme moisture and skin brightening)!

Making The Connection 

Experience the skin transformation M.A.D SYNPLA brings to you and your clients. Nourish the skin and provide the healthy communication necessary to produce new collagen, boost elasticity, and help keep skin plump. And of course, replenish vital growth factors, closing the loop by bringing skin back to a youthful appearance!

Perfect to use pre and post-spa device treatments including micro-needling, nano fusion, oxygen facials, and microdermabrasion, make the SYNPLA Connection.

Leave a Comment