When it comes to fighting the relentless march of time on our skin, the real heroes might not be your classic retinols or peptides—but rather powerful cellular coenzymes and their precursors. Enter the next-gen ingredient technology of Nicotinamide Mononucleotide (NMN) and Nicotinamide Adenine Dinucleotide (NAD+).
These powerhouse molecules are at the forefront of both medical and spa skincare, promising to tackle the root causes of aging at the cellular level. Let’s break down what they are, why your skin loves them, and how two brands – IOKA Skin+Science and TalaDerma, recently launched at IECSC Las Vegas – are revolutionizing results with this science.
August 2025 L+A Report
Science of Regenerative Esthetic Treatments for Skin Laxity
Regenerative esthetics is rapidly redefining the way skincare professionals approach age-related concerns—particularly skin laxity. As a specialized branch of regenerative medicine, this evolving discipline prioritizes the restoration and revitalization of the skin’s natural structure and function.
According to The Evolving Field of Regenerative Esthetics, the path forward requires a fresh look at how we define aging skin, the challenges of soft tissue degeneration, and the clinical goals of regenerative therapies.
Look for Regenerative Esthetic Solutions from BioSkin Aesthetics, SkinAct, Rezenerate, Roccoco Botanicals, IOKA + TiZO for sponsoring this article.
What Are Nicotinamide Adenine Dinucleotide (NAD+) + Nicotinamide Mononucleotide (NMN)
Nicotinamide Mononucleotide (NMN)
NMN is a direct precursor to NAD+.
Think of it as raw fuel or a critical puzzle piece that your body converts into NAD+ through natural metabolic pathways.
NMN supports:
- Energy production
- DNA repair
- Healthy cellular turnover
Nicotinamide Adenine Dinucleotide (NAD+)
NAD+ is a coenzyme found in every living cell.
It’s essential for mitochondrial function, which means it powers the engines of your cells.
NAD+ also plays a role in:
- DNA repair
- Inflammation regulation
- Controlling oxidative stress
—all key players in visible skin aging.
Their Impact on Skin: Why Should You Care?
As we age, NAD+ levels naturally decline—by the time you hit your 40s and 50s, your cells may have about half the NAD+ they did in your 20s. This decline leads to:
- Slower cellular turnover (hello, dullness and fine lines)
- Less efficient DNA repair (cue more sun damage and pigmentation)
- Decreased barrier function (which means dryness and sensitivity)
By either supplying NAD+ directly or boosting it through precursors like NMN, advanced skincare can supercharge the skin’s ability to repair, renew, and defend itself. It’s like flipping on the lights in a room that was growing dimmer with age.
Two Brands Leading the Charge
IOKA Skin+Science Uses Nicotinamide Mononucleotide (NMN) in Modern Skincare
IOKA isn’t just riding the NAD+ trend—they’re setting the standard. Their philosophy is rooted in empowering the skin’s innate ability to heal itself, focusing on NAD+ precursor technology.
How they do it:
- They incorporate NMN and Niacinamide (another NAD+ precursor) to upregulate NAD+ levels in the skin.
- This helps combat visible signs of aging—fine lines, wrinkles, hyperpigmentation—by literally energizing the skin from within.
- They also blend in ceramides, essential bioactive lipids making up 30-40% of your skin’s outer layer, to lock in hydration and protect newly revitalized cells.
Product Spotlight: Firming Serum with DMAE
This serum marries NAD+ precursor technology with DMAE for firming, alongside potent peptides and antioxidants. It’s a powerhouse formula that firms and replenishes while driving NAD+ production deeper.
TalaDerma Uses Nicotinamide Adenine Dinucleotide, NAD+ In Modern Skincare
Brand new for 2025! TalaDerma Founder, Karla Barrick, Nurse and Esthetician, on her inspiration for creating the brand, “TalaDerma was created to elevate results from advanced treatments by addressing what often gets overlooked: what happens after. Most post-care products aren’t designed to complement devices and advanced modalities. I wanted formulas that support skin recovery at the cellular level, using clinically backed ingredients like NAD+ to strengthen, calm, and help prevent complications. TalaDerma gives professionals a smarter way to protect their clients’ investment and amplify long-term results.”
How they do it:
- TalaDerma uses bioactive NAD+ itself in their formulations—giving skin a direct infusion of this cellular coenzyme.
- The line is designed specifically for between treatments, optimizing recovery from procedures like microneedling, RF microneedling, or chemical peels.
Product Spotlight: VitaFirm Ampoule
A targeted treatment perfect for professional use or serious home recovery, this ampoule saturates the skin with NAD+ to promote resilience, even tone, and rapid revitalization post-treatment.
Want More?
Explore the TalaDerma Treatment and Home Care Guide to see how to integrate these ampoules into professional protocols and at-home regimens for maximum results.
The Future of Skincare is Cellular
We’ve moved beyond just chasing hydration and collagen. Today’s cutting-edge ingredient technology dives deep—right to the cellular powerhouse level. By focusing on NAD+ and NMN, brands like IOKA Skin+Science and TalaDerma are equipping the skin to age more slowly, heal more quickly, and glow more energetically.
It’s a thrilling time for medical + spa skincare professionals who want to bring truly next-gen solutions to their clients. From boosting post-procedure recovery to delaying intrinsic aging, these NAD+ technologies are poised to become mainstays on your treatment menus and retail shelves.
Want to Stay Ahead of the Curve?
Keep an eye on how these NAD+ and NMN innovations continue to evolve—and how you can incorporate them into your practice for results that go far beyond skin-deep.