Regenerative esthetics is rapidly redefining the way skincare professionals approach age-related concerns—particularly skin laxity. As a specialized branch of regenerative medicine, this evolving discipline prioritizes the restoration and revitalization of the skin’s natural structure and function.
According to The Evolving Field of Regenerative Esthetics, the path forward requires a fresh look at how we define aging skin, the challenges of soft tissue degeneration, and the clinical goals of regenerative therapies.
Thanks to BioSkin Aesthetics, SkinAct, Rezenerate, Roccoco Botanicals, IOKA + TiZO for sponsoring this article.
In this edition of the L+A Report, we explore cutting-edge esthetic treatments that reflect this shift—spotlighting microneedling with peptide- and amino-acid-rich serums, nano-infusion of advanced chemical peels, and powerful home care protocols infused with peptides and antioxidants. Together, these approaches are helping skincare professionals support collagen renewal, cellular repair, and visible skin tightening with a more holistic, science-backed strategy.
Microneedling: A Cornerstone in Regenerative Esthetics
Microneedling—and its more advanced counterpart, radiofrequency (RF) microneedling—has quickly earned its place as one of the most effective device-based treatments in regenerative esthetics, particularly in the fight against skin laxity. By creating controlled micro-injuries in the skin, microneedling stimulates the body’s natural wound-healing process, leading to a marked increase in collagen and elastin production. When RF energy is added to the equation, results are amplified, with deeper dermal remodeling that tightens, firms, and rejuvenates aging skin.
“I love microneedling, it’s one of my favorite treatments for my skin! I’ve had it more times than I can count!” shares Barry Eichner, Co-Founder of Lipgloss + Aftershave. As an advocate and frequent patient, Barry’s enthusiasm reflects the growing demand from consumers who are looking for non-surgical, results-driven treatments that offer visible improvements in tone, texture, and firmness.
Dr. Vincent Wong on Microneedling
Scientific research backs the buzz. As noted in The Role of Home Care Products in Enhancing Recovery from Microneedling Treatments by Dr. Vincent Wong, “Microneedling has become a prominent cosmetic procedure, praised for its ability to stimulate collagen production through controlled injury to the skin.” He emphasizes that post-treatment care plays a pivotal role in treatment outcomes. Patients who follow up their in-clinic treatments with high-quality, active ingredient-rich home care—especially formulations packed with peptides, antioxidants, and amino acids—often experience faster healing and longer-lasting results.
Whether used alone or paired with advanced serums, growth factors, or RF energy, microneedling continues to evolve as a cornerstone treatment in regenerative esthetics, offering clients a safe, science-backed solution to restore skin’s youthful bounce and resilience.
Peptides + Amino Acids: The Essential Regenerative Ingredients
In both medical and spa esthetic settings, peptides and amino acids have emerged as foundational ingredients in the evolution of regenerative skincare. Whether incorporated into in-clinic treatment protocols or integrated into daily home care routines, these powerhouse actives are essential in supporting skin repair, enhancing treatment outcomes, and improving overall skin health.
“Regenerative esthetic cosmeceuticals are becoming more and more ingredient-driven. Professional-use and home care products have evolved. These targeted treatment products have to include active ingredients that can speed up the recovery process after aggressive treatments,” explains Barry Eichner, Co-Founder of Lipgloss + Aftershave. As esthetic treatments become more advanced and intentionally aggressive—whether microneedling, RF, laser, or chemical resurfacing—the importance of pairing them with scientifically backed recovery support becomes critical.
At the molecular level, peptides—short chains of amino acids—are the precursors to larger proteins like collagen and elastin. Their multifunctional role in skincare makes them an ideal fit for regenerative protocols. As outlined in The Role of Home Care Products in Enhancing Recovery from Microneedling Treatments by Dr. Vincent Wong, “Composed of short chains of amino acids, peptides serve as the fundamental building blocks for larger proteins, including collagen and elastin. Their role in skin care is multifaceted. For instance, certain peptides can stimulate collagen synthesis, while others may enhance skin elasticity and enhance moisture retention by reinforcing the skin’s barrier function.”
This synergistic action not only boosts the efficacy of in-office treatments like microneedling but also supports ongoing recovery and repair. Peptides and amino acids can calm inflammation, reduce visible redness, and help rebuild compromised skin—making them essential in the post-procedure phase and beyond. For clients, continuing use of peptide-rich home care products helps extend and maintain the results of professional treatments while ensuring the skin remains resilient, hydrated, and firm.
SkinAct: Regenerative Microneedling Powered by Technology + Targeted Serums
SkinAct is helping to drive the regenerative esthetics movement forward by equipping medical and spa skincare professionals with advanced tools that deliver visible results. For clients seeking to address skin laxity through collagen stimulation and cellular rejuvenation, SkinAct offers a synergistic pairing of device and serum that enhances both treatment performance and outcomes.
Their Pro Wireless Microneedling Pen with EMS & Light Therapy is a groundbreaking skincare device that utilizes micro-needles to create controlled micro-injuries on the skin’s surface—activating the body’s natural healing response and encouraging the production of collagen and elastin. The device integrates microcurrent (EMS) technology to enhance cellular activity and improve muscle tone, resulting in firmer, more contoured skin. The added benefit of light therapy allows professionals to tailor treatments by targeting inflammation, stimulating collagen, and refining skin tone and clarity. It’s a multifunctional platform that aligns beautifully with today’s regenerative protocols.
To elevate results even further, SkinAct pairs this advanced device with their Collagen + Peptide Duo Serum—a clinical-grade, anti-aging formulation designed for both in-office treatments and take-home care. This powerhouse serum blends a triple-collagen complex, Matrixyl® 3000 peptides, and a hyaluronic acid fusion to deliver deep hydration, support skin structure, and soften the appearance of fine lines. Designed to penetrate multiple layers of the skin, it offers both instant and long-term benefits, making it a favorite among estheticians looking for high-performance, results-driven skincare.
Together, this duo provides a professional-grade regenerative experience that’s perfectly aligned with the needs of today’s discerning skincare clients—those who want more than just surface-level results and are ready to invest in science-backed solutions that truly transform skin.
BioSkin Aesthetics: A Triple Threat in Regenerative Esthetics
For skincare professionals ready to offer a multi-dimensional approach to treating skin laxity, BioSkin Aesthetics delivers a powerhouse lineup of regenerative tools designed to work in synergy. With an innovative combination of microneedling, amino acid infusion, and chemical peeling, BioSkin Aesthetics helps medspa and spa professionals deliver dramatic, science-backed results that go beyond the surface to rebuild skin integrity and firmness from within.
At the heart of the BioSkin Aesthetics approach is the BioTouch Precision™, a professional microneedling device that allows practitioners to infuse regenerative serums directly into the skin with pinpoint precision. This delivery system maximizes the penetration of active ingredients, setting the stage for meaningful cellular repair and renewal.
Professionals can pair the device with the Sera AK Firming serum—an advanced formula enriched with 10 amino acids known for their firming, hydrating, and antioxidant benefits. These amino acids help fuel collagen production, support barrier function, and reinforce skin structure, making this serum an ideal companion for microneedling and other advanced modalities.
To complete the trifecta, BioSkin Aesthetics offers BioRePeelCl3—a dual-phase topical TCA chemical peel that addresses skin laxity and texture at a deeper level. This peel is not only formulated with trichloroacetic acid (TCA), a proven collagen stimulator, but also enhanced with regenerative amino acids, including Glycine, Proline, Hydroxyproline, and Arginine—each selected for their ability to encourage dermal remodeling and skin firming.
Together, this three-step protocol—microneedling with BioTouch Precision™, amino acid infusion via Sera AK Firming, and chemical exfoliation using BioRePeelCl3—offers a comprehensive regenerative strategy. It gives estheticians and medical providers a powerful way to visibly improve skin laxity, while supporting long-term skin health and rejuvenation.
Chemical Peels: A Foundational Regenerative Treatment
In the realm of regenerative esthetics, chemical peels remain one of the most accessible, customizable, and results-driven treatments available to skincare professionals. Whether performed in a medical spa or traditional spa setting, chemical peels offer a powerful way to jumpstart cellular turnover, stimulate collagen production, and address a wide variety of skin concerns—all while supporting the long-term goal of improved skin health and resilience.
Terri Wojak on Chemical Peels
As Terri Wojak, a respected industry educator, explains:
“Peels are beneficial for many skin conditions, including aging, acne, hyperpigmentation, and even sensitive skin. Increasing the rate of exfoliation and triggering collagen production improves the visible signs of aging. One of the contributing factors to acne is dead skin cells accumulated in the follicle, along with excess sebum and C. acnes bacteria. Through proper exfoliation, we are getting rid of the accumulated dead skin, and the acidity level fights bacteria.
Hyperpigmentation is formed when melanocytes produce melanin to protect keratinocytes. Peels help reduce hyperpigmentation by exfoliating the melanin-filled cells. Sensitive skin is usually indicative of an impaired barrier. Gentle peels improve the barrier by getting rid of damaged cells and stimulating the production of new healthy cells. Regardless of the concern, a thorough assessment of the client’s skin is necessary to ensure there are no contraindications.”
Peels offer regenerative benefits across the board—from superficial exfoliation with enzymes or alpha hydroxy acids (AHAs) to medium-depth TCA peels that stimulate fibroblast activity and dermal remodeling. For skin laxity in particular, chemical peels that include collagen-stimulating actives such as trichloroacetic acid, mandelic acid, or amino acid blends can be highly effective in promoting firmness and tone while also smoothing texture and evening pigment.
Because peels are so versatile, they can be easily layered into many treatment plans—paired with microneedling, LED therapy, or nano-infusion—or used as a standalone service with minimal downtime. For professionals looking to expand their regenerative treatment offerings, chemical peels provide a reliable and results-oriented entry point with countless customization options
NanoInfusion + Chemical Peels: Gentle Yet Powerful with Rezenerate
For clients who want regenerative results without the downtime, Rezenerate’s NanoFacial offers a groundbreaking alternative that delivers both efficacy and comfort. This gentle, non-invasive approach to skin rejuvenation utilizes advanced nanotechnology to dramatically improve product absorption, making it a standout option for medical and spa skincare professionals looking to treat skin laxity, pigmentation, and fine lines with precision and care.
The Rezenerate NanoFacial temporarily disrupts the skin’s protective barrier to increase product absorption by up to 40–50%, compared to the typical 2–10% seen with traditional topical application. This cutting-edge delivery system allows active ingredients—whether from chemical peels or regenerative serums—to work more effectively, reaching deeper layers of the skin without the trauma associated with more aggressive modalities.
“When the NanoFacial is used for the delivery of no-downtime chemical peels—such as the Linder Health Polite and Hero Peels or Sorella Peel Pads—the use of nanotechnology increases absorption and boosts corrective results,” explains Rezenerate. “This gentle yet effective approach allows for maximum impact without irritation, making it ideal for treating pigmentation, fine lines, and texture.”
In addition to chemical peels, nanotechnology also significantly enhances the delivery of peptide- and amino acid-rich serums—making it an ideal modality for regenerative esthetic protocols. When paired with formulations that contain collagen-stimulating peptides, barrier-repairing amino acids, or antioxidant complexes, the Rezenerate NanoFacial helps amplify their performance, ensuring optimal efficacy and visible results with minimal downtime.
By combining non-invasive exfoliation with precision product delivery, Rezenerate has created a truly modern approach to esthetics that supports collagen production, refines skin texture, and strengthens the skin’s natural resilience—all while prioritizing client comfort and recovery.
Peptide-Rich Home Care: Essential Support for Regenerative Results
The success of any regenerative esthetic treatment doesn’t end in the treatment room—it continues at home. Professional microneedling, nano-infusion, and chemical peel protocols lay the groundwork for change, but it’s the home care regimen that carries those results across the finish line.
“Skincare professionals need to express to their clients that home care is not negotiable. Clients will see faster and more sustainable results when incorporating the recommended home care routine. Some pros will not even treat clients without a retail purchase.” Jenni Nagle, Co-Founder of Lipgloss + Aftershave. When clients commit to using peptide-rich, growth factor-infused, and amino acid-enhanced formulations post-treatment, they help sustain the momentum of collagen stimulation and accelerate the skin’s natural recovery processes.
As Dr. Vincent Wong explains:
“The efficacy of microneedling treatments can be heightened significantly through the thoughtful selection of home care products in the weeks following the procedure. By integrating advanced formulations rich in exosomes, growth factors, peptides, and innovative ingredients like xanthohumol and KP1, patients can boost their healing process and sustain the long-term benefits of collagen synthesis.
Ultimately, a comprehensive home care routine, emphasizing quality ingredients and targeted support, can pave the way for visible results, allowing individuals to enjoy the full impact of their microneedling treatment. With the right approach, patients can experience not just immediate improvements but enduring skin vitality and youthfulness.”
Peptides, in particular, are a cornerstone of regenerative home care. These short chains of amino acids not only help rebuild collagen and elastin but also reduce inflammation, improve hydration, and support barrier repair—all essential in the days and weeks following an in-office treatment. When paired with ingredients like hyaluronic acid, exosomes, niacinamide, or even antioxidants like xanthohumol, peptide-based products provide a powerful synergy that elevates the skin’s ability to heal, renew, and maintain firmness.
From firming serums and recovery balms to growth-factor-enriched creams, peptide-rich home care is no longer a luxury—it’s a necessity for any client looking to optimize their investment in regenerative esthetics. Professionals who educate clients on the science behind post-treatment support not only drive better results but also build trust and long-term loyalty through visible, lasting outcomes.
Peptide-Rich Home Care: Roccoco Botanicals Redefines Performance Skincare
When it comes to regenerative esthetics, home care isn’t just a maintenance step—it’s an extension of the treatment itself. For clients seeking to maintain the firming, brightening, and collagen-stimulating effects of microneedling or chemical peels, Roccoco Botanicals offers one of the most intelligent and science-backed formulations in the professional skincare space.
The brand’s Peptide Finisher stands out as a next-generation treatment serum, expertly formulated to enhance collagen synthesis, neutralize free radicals, and deliver sustained antioxidant protection. At its core is Palmitoyl Tetrapeptide-7, a well-researched peptide renowned for its ability to reduce inflammation and stimulate the production of collagen and hyaluronic acid—two key players in skin firmness and elasticity.
What truly sets this product apart is its cutting-edge delivery technology. Peptide Finisher features pure L-Ascorbic Acid encapsulated in gold particles and coated with phospholipids—a breakthrough system that enables deep penetration into the skin while ensuring vitamin C remains stable and bioavailable. This encapsulation technique prevents oxidation and allows for a controlled, sustained release of the active, resulting in brighter, firmer skin over time.
To amplify these effects, the formula also includes Glutathione, a master antioxidant that not only enhances the absorption of vitamin C but also regenerates oxidized vitamin C back to its active state, ensuring prolonged antioxidant activity. The result? A peptide-rich, antioxidant-charged home care solution that works deeper, faster, and more effectively than traditional serums.
For professionals looking to recommend high-performance post-treatment care that complements in-office regenerative services, Peptide Finisher by Roccoco Botanicals is a standout choice—offering science, stability, and visible skin transformation in every drop.
Peptide-Rich Home Care: IOKA Skincare Delivers Moisture + Muscle Relaxation
In the world of regenerative esthetics, high-performance home care is essential to maintaining the results achieved in the treatment room. IOKA Skincare has emerged as a leader in this space, offering innovative peptide-based formulations that do more than support skin health—they transform it. With a focus on scientifically backed ingredients and advanced delivery systems, IOKA helps clients extend their collagen gains and maintain smooth, hydrated, and youthful-looking skin.
One of the brand’s newest products, the Peptide Lift Serum, blends collagen-boosting peptides with wrinkle-smoothing neuropeptides to create a powerful, multifunctional formula. At the heart of the serum is Copper Tripeptide-1, a naturally occurring peptide complex proven to stimulate fibroblasts and promote the production of collagen and elastin—essential structural proteins that give skin its firmness and bounce. Copper peptides are also known to enhance wound healing, improve scar appearance, and regulate pigmentation, making this an ideal serum for post-procedure use or daily age defense.
In addition to structural support, the formula includes Argireline® (Acetyl Hexapeptide-8), one of the most well-known neuropeptides in esthetics. Often referred to as a “Botox-like peptide,” Argireline® works by inhibiting muscle contractions involved in expression lines, softening the appearance of frown lines, crow’s feet, and forehead creases—without the need for injectables.
IOKA also offers a peptide-infused moisturizer designed to reinforce barrier function and lock in hydration, while utilizing a targeted delivery system that ensures peptides are effectively absorbed into the skin. This dual-action approach—hydration plus regeneration—helps preserve treatment results and restore skin’s youthful vitality.
Together, IOKA’s peptide-focused formulations offer an intelligent and results-driven approach to home care that aligns perfectly with today’s regenerative esthetic protocols. Whether addressing skin laxity, wrinkles, or post-procedure recovery, IOKA gives professionals the tools to keep the results going strong long after clients leave the treatment room.
SPF: The Non-Negotiable in Regenerative Esthetics
In regenerative esthetics, where the focus is on rebuilding collagen, enhancing skin elasticity, and restoring a youthful appearance, daily sunscreen use is not optional—it’s essential. Treatments like microneedling, chemical peels, and nano-infusion create controlled injury and encourage new cell growth, but without proper sun protection, UV exposure can undo this progress and accelerate skin aging.
“There are so many options to meet the needs for every client; matte finish, tinted, sticks, lip protection…the list goes on. There is no reason your clients shouldn’t be wearing SPF.” Jenni Nagle, Co-Founder of Lipgloss + Aftershave.
Not wearing an SPF is counterintuitive to the goals of regenerative esthetics. UV radiation is a known culprit in the breakdown of collagen and elastin, the very proteins professionals are working so hard to restore. As noted by the National Library of Medicine:
“The sun’s ultraviolet light can cause major damage to the skin. The outer layer of the skin has cells that contain the pigment melanin. Melanin protects skin from the sun’s ultraviolet rays. These can burn the skin and reduce its elasticity, leading to premature aging…”
Mineral-based SPFs offer a unique advantage in both protection and compatibility with sensitive or compromised skin. As highlighted in the L+A Editorial Shedding Some Light on SPF:
“Zinc and Titanium Dioxide protect from hyperpigmentation, heat, and UV radiation by forming a physical shield on the surface. This shield keeps the skin cool, prevents pollution from absorbing, and is very helpful for clients with impaired barrier function, acne, rosacea, and hyperpigmentation.
Physical sunscreens aren’t absorbed by the skin, aren’t degraded by sunlight, and are more stable over time.”
For patients recovering from regenerative procedures—or simply looking to maintain firm, youthful skin—a daily SPF of 30 or higher with physical blockers like zinc oxide or titanium dioxide is a must. It not only safeguards the skin from damaging UV rays but also helps preserve the integrity of newly formed collagen and prevent pigmentation triggers that can arise post-treatment.
Incorporating SPF education into every client consultation isn’t just good skincare—it’s a cornerstone of successful, long-term regenerative outcomes.
Daily SPF for Home Care: TiZO Delivers Science-Backed Sun Protection in Style
When it comes to merging cutting-edge sun protection with luxurious wearability, TiZO continues to lead the charge in the medical and spa skincare industry. Known for its commitment to science, stability, and skin compatibility, TiZO has become a trusted favorite among professionals and clients alike—especially when it comes to recommending daily SPF for home care.
Their newest launch, the TIZO® Tinted Moisturizing Serum SPF 30, is a game-changer in regenerative esthetics. This serum-meets-sunscreen hybrid combines high-level mineral protection with skin-loving ingredients and a silky, serum-like texture that feels as good as it performs. Available in five radiant, flexible shades, this multitasking formula offers customizable coverage that complements a wide range of skin tones, making it an ideal choice for daily wear.
What sets this SPF apart is its next-level delivery system—designed to evenly disperse zinc oxide while preserving an ultra-lightweight, cosmetically elegant finish. It’s a product your clients will actually want to wear every day, which is half the battle when it comes to compliance with sun protection recommendations.
The formula also goes beyond UV protection. It’s enriched with ceramides to help support and strengthen the skin barrier, and features a sophisticated hyaluronic acid complex containing seven different molecular weights—ensuring hydration at multiple levels of the skin for both instant and long-lasting moisture. Glycerin boosts the formula’s humectant benefits, making it a perfect companion for post-treatment or everyday use.
In a field where daily SPF is essential for preserving treatment outcomes and preventing photoaging, the TiZO Tinted Moisturizing Serum SPF 45 offers the kind of multifunctional protection that clients appreciate and professionals can feel confident recommending. It’s skincare, sun care, and sheer wearable beauty—rolled into one intelligent formula.