In beauty, trends often come and go—but every so often, an ingredient emerges that quietly reshapes how we think about skin health. Succinic acid is one of those rare finds. Long familiar to biochemists and medical researchers, it is now stepping into the spotlight as a multifunctional, skin-intelligent molecule capable of supporting everything from anti-aging and acne control to rosacea management and tissue regeneration.
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Gwendolyn Howard, CLT and LE
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What makes succinic acid especially compelling is that it doesn’t simply act on the surface. Instead, it works at the crossroads of metabolism, inflammation, and cellular energy, aligning perfectly with the industry’s growing shift toward bioenergetic and regenerative skin care.
From Amber to Cell Energy: A Brief History of Succinic Acid
Succinic acid was first identified centuries ago after being extracted from amber—hence its name, derived from the Latin succinum. Chemically, it is a small dicarboxylic acid, but biologically, it plays a much larger role. It is a natural component of the Krebs cycle, the fundamental process through which our cells generate energy.
In human physiology, succinic acid exists in every tissue, including the skin. For decades, its role was considered purely metabolic. Today, however, we know that succinate is also a signaling molecule, capable of influencing inflammation, blood vessel formation, and tissue repair—functions that are highly relevant to modern cosmetic dermatology.
How Succinic Acid Communicates with Skin Cells
One of the most exciting discoveries surrounding succinic acid is its interaction with the GPR91 receptor, a cell-surface receptor found in key skin cells such as keratinocytes, fibroblasts, endothelial cells, and immune cells like macrophages.
When succinic acid binds to GPR91, it triggers a cascade of signals that help regulate inflammation, vascular activity, and regenerative responses. At the same time, succinic acid supports mitochondrial energy production, increasing the availability of ATP—the fuel required for collagen synthesis, epidermal renewal, and wound repair.
This dual action—cell signaling plus bioenergetic support—is what sets succinic acid apart from many conventional cosmetic acids.
8 Places We See Succinic Acid Today: Cosmetic and Supplement Uses
1 Topical Formulations
In topical skincare, succinic acid is appearing in serums, creams, and treatment gels, particularly those designed for sensitive, acne-prone, or redness-prone skin. Rather than aggressively exfoliating, it focuses on:
- Reducing inflammation
- Regulating sebum
- Supporting barrier recovery
This makes it an appealing option for consumers who want results without irritation.
2 Chemical Peelings
Succinic acid–based chemical peels represent a new generation of biological peelings. Instead of forcing rapid exfoliation, these treatments stimulate cellular activity while maintaining skin comfort. They are increasingly used in patients who cannot tolerate traditional acids—especially those with rosacea or mature skin.
3 Injectable Innovation: Xela Rederm®
One of the most advanced applications of succinic acid is Xela Rederm® by Hyalual, a patented injectable that combines succinic acid with high–molecular weight, non-crosslinked hyaluronic acid. Unlike classic products, this injectable does not aim to add volume. Instead, it enhances:
- Tissue hydration
- Oxygen utilization
- Cellular energy metabolism
The result is improved skin quality, elasticity, and luminosity—an approach aligned with the concept of regenerative aesthetics.
4 Oral Supplementation
Succinic acid is also available as an oral supplement, valued for its systemic antioxidant and metabolic benefits. In dermatology, supplementation is gaining interest as an adjunct strategy for inflammatory skin conditions, skin aging, and impaired wound healing.
5 Anti-Aging: Energy as the New Youth Factor
Aging skin is not only about wrinkles—it is also about declining cellular energy and chronic low-grade inflammation. Succinic acid addresses both. By supporting mitochondrial function and modulating inflammatory pathways, it helps improve:
- Skin texture and firmness
- Dermal density
- Overall radiance
When used across topical, injectable, and oral routes, succinic acid fits seamlessly into modern anti-aging protocols focused on skin vitality rather than overcorrection.
6 Acne: Calm, Not Aggression
In acne-prone skin, succinic acid offers a refreshing alternative to traditionally harsh treatments. Its benefits include:
- Anti-inflammatory action
- Sebum regulation
- Support of skin microbiome balance
This makes it particularly suitable for adult acne and sensitive acne-prone patients, where inflammation plays a larger role than excess oil alone.
7 Rosacea: Emerging Clinical Evidence
Rosacea remains one of the most challenging conditions in cosmetic dermatology due to its sensitivity and vascular component. Recent evidence—including my published clinical work (Journal of Cosmetic Dermatology, DOI: 10.1111/jocd.70484)—highlights succinic acid’s potential to reduce erythema, improve skin tolerance, and enhance overall skin quality.
These effects are likely linked to its ability to modulate inflammatory signaling, support mitochondrial resilience, and improve vascular balance—key factors in rosacea-prone skin.
8 Wound Healing and Compromised Skin
Beyond aesthetics, succinic acid has demonstrated value in wound healing and regenerative medicine, including chronic ulcers and diabetic foot management. When combined with other bioactive compounds—such as hyaluronic acid, peptides, and amino acids—it supports:
- Angiogenesis
- Fibroblast activation
- Controlled immune responses
These same mechanisms are increasingly relevant in post-procedure recovery and skin barrier repair within aesthetic practice.
What’s Next for Succinic Acid?
Current research is exploring:
- Advanced delivery systems for improved skin penetration
- Combination formulas targeting mitochondrial aging
- Personalized protocols based on inflammatory and metabolic skin profiles
As beauty continues to move toward science-backed, skin-intelligent solutions, succinic acid is well-positioned to expand its role across cosmetic and aesthetic medicine.
So, Why Succinic Acid Earns the Title of “Superingredient”
Succinic acid is more than just another acid—it is a cellular activator, metabolic supporter, and inflammation modulator. Its versatility across skincare, injectables, and supplementation reflects a broader shift in beauty: from surface correction to deep skin health and regeneration. For professionals and consumers alike, succinic acid represents the future of smart, energy-driven skincare.
Contribution by Dr. Alberto Leguina
Dr. Alberto Leguina-Ruzzi is a Biologist, Doctor of Medical Sciences, Physician, and Dermatology Specialist with more than a decade of experience across biomedical research, university teaching, clinical practice, and the pharmaceutical industry.
He currently serves as President of the Chilean Chapter of ISWAM (International Seminar and Workshop in Aesthetic Medicine) and has shared his expertise on stages around the globe—including IMCAS, MEIDAN, SOCHIMCE, AIDA, and 5-CC, among other major international congresses.
Throughout his career, Dr. Alberto has led continuing medical education initiatives, offered scientific and technical support to sales teams, and ensured the ethical, accurate, and clinically relevant communication of medical and pharmaceutical innovations.