A clinically adaptable treatment philosophy designed for every stage of advanced aesthetic care.
Since 2010, Lira Clinical has stood as a global leader in professional skincare innovation – bridging the gap between beauty and medical aesthetics. Known for their proprietary MASQ-tech™, Smart Peels™, deep delivery systems, plant stem cell & peptide technology, and more, Lira Clinical has earned its reputation as a science-driven brand trusted in clinical environments worldwide. For over a decade, professionals have relied on Lira’s formulations for purely transformative clinical results. And in addition, the education empowers providers to deliver consistent, visible, and safe results.
In August, Lipgloss + Aftershave introduced readers to one of the brand’s newest professional resources, the Lira Clinical Regeneration Clinical Treatment Guide 2025, in the article “Preparing + Maintaining Skin Through Advanced Medical Aesthetic Treatment Plans.” The guide is more than a treatment manual; it’s a strategic blueprint for building long-term skin health through progressive treatments.
Thanks To Lira Clinical for Sponsoring This Article.
Introducing the Lira Clinical Regeneration Clinical Treatment Guide 2025
The Lira Clinical Regeneration Clinical Treatment Guide 2025 is designed to help beauty and medical professionals seamlessly integrate progressive hybrids to advanced aesthetic treatment plans. More than a collection of protocols, the guide provides a blueprint for how to assess, prepare, and maintain skin across the full spectrum of clinical procedures. It emphasizes the importance of skin priming, highlights treatment sequences that maximize patient outcomes, and bridges the gap between progressive peels along with medical procedures.
This resource also underscores the long-term value of Hybrid Treatments as a recurring touchpoint for patients. By weaving these treatments into assessment, recovery, and maintenance, professionals can extend the benefits of CO₂ laser, RF microneedling, IPL, fillers, and neurotoxins. The guide reflects Lira Clinical’s commitment to empowering practitioners with science-backed tools that ensure every treatment plan delivers visible and safe results.”
At the heart of this new guide lies a hero GPS2 (Guide and Protect System) treatment that has captured the attention of medical skincare professionals alike, the Regen Hydrating Protocol.
Regen Hydrating Protocol – A Smart, Adaptable Clinical Treatment
Designed to be simple, effective, and customizable, the Regen Hydrating Protocol is a treatment that fits seamlessly into any professional setting. Whether performed as a standalone service or integrated into an advanced treatment plan, this protocol delivers results that patients can see and feel.
Ideal for all skin types, the treatment restores hydration, refines texture, and supports cellular renewal through a blend of bioactive ingredients including MASQ-tech™, vitamin C, hexylresorcinol, enzymes, and biomicroneedling. The result is firmer, brighter, and hydrated skin, making it equally effective as a pre-procedure primer, a post-procedure recovery treatment, or a maintenance facial for ongoing care.
With its exclusive MASQ-tech™, vitamin C, and mandelic acid infusion, this protocol promotes clinical brightening, increases circulation, and encourages youthful cellular turnover, offering a natural alternative to microneedling. It’s a treatment that gives patients noticeable regeneration without downtime.
Regen Hydrating Protocol: Step-by-Step
This professional treatment delivers hydration and renewal with every step, combining the precision of a medical-grade approach with the comfort of a clinical experience.
CLEANSE
Thoroughly cleanse the skin with BIO Enzyme Cleanser, rinse, and repeat. Remove with a tepid barber towel or cleansing sponges to ensure the skin is fully prepped.
PRIME
Apply Primer Plus Solution, part of the Smart Peels™ with gauze to the entire face. Begin with the forehead and move toward the perimeter, cheeks, and nose. This step further refines and clarifies the skin while priming it for active exfoliation.
EXFOLIATE
Mix 5ml of Vita Brite with ½ capful of Green Power, both are part of Lira Clinical Smart Peels™. Using a fan brush, spread evenly across the face and neck, allowing it to rest for 1–2 minutes before massaging into the skin for another 1–2 minutes. Patients will feel a gentle “tingly” sensation similar to microdermabrasion, an indication of the treatment’s activity. Redness may occur and is completely normal. Remove the mixture with a cool barber towel.
BRIGHTEN
Massage 3–4 drops of PRO Lite Serum into the skin until fully absorbed. This step enhances radiance and supports even tone.
HYDRATE
Follow with 1–2 pumps of BIO Caviar Crème, massaged into the skin to restore lipid balance, smooth texture, and deliver deep hydration.
PROTECT
Finish by applying SPF Solar Shield 30 or a BB Créme of choice evenly across the face, neck, and décolleté. Complete the treatment with BIO Lip Factor for nourished, protected lips.
“In cases when the patient experiences discomfort or erythema, use the MYSTIQ Cryo Face Masque to calm and soothe the skin,” the guide recommends.
This clinically engineered sequence allows providers to easily tailor the intensity of exfoliation and hydration for each patient, making it a perfect match for high-performance clinical practices.
Dr. Krystal Briglia on the Lira Clinical Regen Hydrating Protocol’s Use in Her Clinic
“When Lira Clinical sent me the Regen Hydrating Protocol to evaluate in my medical practice, I was immediately impressed by its versatility and performance. This protocol has quickly become one of my favorite go-to treatments in the clinic.
Clinically, I’ve found the Regen Hydrating Protocol to be incredibly useful across multiple stages of patient care. I often use it as a pre-treatment prep before more aggressive procedures, it’s excellent for preparing the skin, building collagen, and ensuring the barrier is healthy and intact before advancing to deeper treatments. It’s also a great standalone or entry-level option for new patients or those just beginning with peels. It introduces the skin to gentle exfoliation and rejuvenation in a safe, controlled way, laying the foundation for more intensive future treatments. Additionally, it serves as a wonderful post-treatment or step-down option, helping the skin recover after aggressive procedures while maintaining hydration and supporting long-term skin health.
From a business perspective, I really appreciate the protocol’s versatility and customization. The treatment can be easily adjusted in strength, used lightly or more aggressively, depending on the patient’s needs. That flexibility reduces the need to stock multiple different peels or products to achieve similar results. It’s an approach that not only improves clinical outcomes but also delivers a strong ROI by streamlining inventory. With one product line serving multiple roles and treatment intensities, we’re able to create highly personalized treatment plans while maximizing efficiency within the practice.
Looking ahead, I’m very interested in expanding the use of the Green Power Peel and other formulations,” Dr. Briglia added. “I’d like to explore defined protocols that leverage these products across a spectrum of intensities, from hydrating, lighter peels to more advanced resurfacing applications. The goal is to continue increasing the versatility and clinical value of these technologies within my practice.
As a next step, I plan to further evaluate and document how different variations of the Hydrating Protocol can enhance patient outcomes,” she concluded. “I also want to educate my staff and patients on its many uses and benefits. This is a truly adaptable, results-driven system, and I’m excited to continue integrating it into our advanced skincare programs at Triada.” Dr. Krystal Briglia, DNP, MBA, NP-C
An Ideal Addition to Advanced Treatment Plans
The Hydrating Protocol is more than a facial; it’s a strategic clinical tool. For providers offering CO₂ laser, microneedling, RF microneedling, HIFU ultrasound, or other intensive modalities, this protocol supports every phase of patient care.
Before procedures, it primes and strengthens the skin, reducing the risk of post-treatment irritation. After advanced treatments, it accelerates healing and maintains hydration, supporting the skin’s regenerative cycle. For maintenance, it keeps the complexion balanced and bright between higher-intensity sessions.
By integrating this protocol into an advanced treatment plan, professionals can create a 360° continuum of care, preparing, rejuvenating, and maintaining skin health through every phase of regeneration.
Education That Elevates Every Practitioner
One of the key pillars of Lira Clinical’s success is its commitment to education. Beyond the products and protocols, the brand invests heavily in the growth of professionals who carry the line.
Purely Clinical Global Skin Affair Tour is a symposium hosted by the Lira Clinical Owners to share the advancements and technological innovations in the industry that are held in the US and worldwide. Interactive Smart Peels™ Studio Classes focus on in-depth product knowledge and clinical application. These events and classes provide countless opportunities for hands-on learning and peer collaboration. These programs empower professionals to confidently implement clinical-grade protocols, ensuring safety, efficacy, and elevated results in every treatment room.
This dedication to ongoing education, in-person and online LiraEDU, is what keeps Lira Clinical at the forefront of professional skincare. It’s not just about formulating cutting-edge products; it’s about empowering professionals with the knowledge to use them to their fullest potential.
Innovation, Education, and Regeneration
As the aesthetics industry continues to evolve, Lira Clinical remains a trusted partner to clinical skincare professionals around the world. Clinical skincare is the bridge between beauty and medical aesthetics. Their commitment to merging science with artistry has resulted in products and protocols that deliver both clinical efficacy and sensory experience.
The Regeneration Clinical Treatment Guide 2025 and its flagship Hydrating Protocol embody that philosophy, smart, versatile, and results-driven. For any provider looking to elevate treatment outcomes while simplifying their clinical workflow, this represents the new standard in modern skin regeneration.